Hideaki Mizuno

Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments

Hironori Fukuda, Kosuke Arai, Hideaki Mizuno, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa …

Cancer Science, Mar 25, 2024

Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer.

Kana Ohashi, Yukari Nishito, Hironori Fukuda, Ryoichi Sadahiro, Yukihiro Yoshida, Shun-Ichi Watanabe, Noriko Motoi, Yukiko Sonobe, Hideaki Mizuno, Hiroyuki Tsunoda …

Scientific reports 14(1) 429-429 2024年1月3日

Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations.

Kazunori Aoki, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa, Eri Hashimoto, Mina Takahashi …

Cancer research communications 3(6) 1026-1040 2023年6月査読有り

Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion.

Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno …

mAbs 15(1) 2253570-2253570 2023年

Digital workflows for pathological assessment of rat estrous cycle stage using images of uterine horn and vaginal tissue

Shinichi Onishi, Riku Egami, Yuya Nakamura, Yoshinobu Nagashima, Kaori Nishihara, Saori Matsuo, Atsuko Murai, Shuji Hayashi, Yoshifumi Uesumi, Atsuhiko Kato, Hiroyuki Tsunoda, Masaki Yamazaki, Hideaki Mizuno

Journal of Pathology Informatics, 100120-100120, Jun, 2022 Peer-reviewedLast authorCorresponding author

Geography-Dependent Horizontal Gene Transfer from Vertebrate Predators to Their Prey.

Chiaki Kambayashi, Ryosuke Kakehashi, Yusuke Sato, Hideaki Mizuno, Hideyuki Tanabe, Andolalao Rakotoarison, Sven Künzel, Nobuaki Furuno, Kazuhiko Ohshima, Yoshinori Kumazawa, Zoltán T Nagy, Akira Mori, Allen Allison, Stephen C Donnellan, Hidetoshi Ota, Masaki Hoso, Tetsuya Yanagida, Hiroshi Sato, Miguel Vences, Atsushi Kurabayashi

Molecular biology and evolution, 39(4), Apr 10, 2022 Peer-reviewed

Anti-GPRC5D/CD3 bispecific T cell-redirecting antibody for the treatment of multiple myeloma.

Kodama T, Kochi Y, Nakai W, Mizuno H, Baba T, Habu K, Sawada N, Tsunoda H, Shima T, Miyawaki K, Kikushige Y, Mori Y, Miyamoto T, Maeda T, Akashi K

Molecular cancer therapeutics, 18(9) 1555-1564, Jul, 2019 Peer-reviewed

ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor

Yoshito Nakanishi, Hideaki Mizuno, Hitoshi Sase, Toshihiko Fujii, Kiyoaki Sakata, Nukinori Akiyama, Yuko Aoki, Masahiro Aoki, Nobuya Ishii

MOLECULAR CANCER THERAPEUTICS, 14(12) 2831-2839, Dec, 2015 Peer-reviewed

The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC

Y. Takahashi, P. Sheridan, A. Niida, G. Sawada, R. Uchi, H. Mizuno, J. Kurashige, K. Sugimachi, S. Sasaki, Y. Shimada, K. Hase, M. Kusunoki, S. Kudo, M. Watanabe, K. Yamada, K. Sugihara, H. Yamamoto, A. Suzuki, Y. Doki, S. Miyano, M. Mori, K. Mimori

ANNALS OF ONCOLOGY, 26(5) 935-942, May, 2015 Peer-reviewed

The PFA-AMeX method achieves a good balance between the morphology of tissues and the quality of RNA content in DNA microarray analysis with laser-capture microdissection samples

Takeshi Watanabe, Atsuhiko Kato, Hiromichi Terashima, Koichi Matsubara, Yu Jau Chen, Kenji Adachi, Hideaki Mizuno, Masami Suzuki

JOURNAL OF TOXICOLOGIC PATHOLOGY, 28(1) 41-47, Jan, 2015 Peer-reviewed

Topological analysis of gene expression arrays identifies high risk molecular subtypes in breast cancer

Javier Arsuaga, Nils A. Baas, Daniel DeWoskin, Hideaki Mizuno, Aleksandr Pankov, Catherine Park

APPLICABLE ALGEBRA IN ENGINEERING COMMUNICATION AND COMPUTING, 23(1-2) 3-15, Apr, 2012 Peer-reviewed

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

William A. Freed-Pastor, Hideaki Mizuno, Xi Zhao, Anita Langerod, Sung-Hwan Moon, Ruth Rodriguez-Barrueco, Anthony Barsotti, Agustin Chicas, Wencheng Li, Alla Polotskaia, Mina J. Bissell, Timothy F. Osborne, Bin Tian, Scott W. Lowe, Jose M. Silva, Anne-Lise Borresen-Dale, Arnold J. Levine, Jill Bargonetti, Carol Prives

CELL, 148(1-2) 244-258, Jan, 2012 Peer-reviewed

Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

Hirokazu Okayama, Takashi Kohno, Yuko Ishii, Yoko Shimada, Kouya Shiraishi, Reika Iwakawa, Koh Furuta, Koji Tsuta, Tatsuhiro Shibata, Seiichiro Yamamoto, Shun-ichi Watanabe, Hiromi Sakamoto, Kensuke Kumamoto, Seiichi Takenoshita, Noriko Gotoh, Hideaki Mizuno, Akinori Sarai, Shuichi Kawano, Rui Yamaguchi, Satoru Miyano, Jun Yokota

CANCER RESEARCH, 72(1) 100-111, Jan, 2012 Peer-reviewed

Molecular classification of prostate cancer using curated expression signatures

Elke K. Markert, Hideaki Mizuno, Alexei Vazquez, Arnold J. Levine

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(52) 21276-21281, Dec, 2011 Peer-reviewed

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

Hideaki Mizuno, Benjamin T. Spike, Geoffrey M. Wahl, Arnold J. Levine

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(52) 22745-22750, Dec, 2010 Peer-reviewedLead author

Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome

Hideaki Mizuno, Gurinder Atwal, Haijian Wang, Arnold J. Levine, Alexei Vazquez

BMC GENETICS, 11 27, Apr, 2010 Peer-reviewedLead author

PrognoScan: a new database for meta-analysis of the prognostic value of genes

Hideaki Mizuno, Kunio Kitada, Kenta Nakai, Akinori Sarai

BMC MEDICAL GENOMICS, 2 18, Apr, 2009 Peer-reviewedLead author

A signature-based method for indexing cell cycle phase distribution from microarray profiles

Hideaki Mizuno, Yoshito Nakanishi, Nobuya Ishii, Akinori Sarai, Kunio Kitada

BMC GENOMICS, 10 137, Mar, 2009 Peer-reviewedLead author

Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma

Hidemi Saito, Yukiko Inagaki, Toshiaki Tsunenari, Masako Ura, Hideaki Mizuno, Kaori Fujimoto-Ouchi, Etsuro Onuma, Koh Sato, Etsuro Ogata, Hisafumi Yamada-Okabe

CANCER SCIENCE, 98(10) 1563-1569, Oct, 2007 Peer-reviewed

ORI-GENE: gene classification based on the evolutionary tree

H Mizuno, Y Tanaka, K Nakai, A Sarai

BIOINFORMATICS, 17(2) 167-173, Feb, 2001 Peer-reviewedLead author

The Dictyostelium developmental cDNA project: Generation and analysis of expressed sequence tags from the first-finger stage of development

Takahiro Morio, Hideko Urushihara, Tamao Saito, Yoshihiro Ugawa, Hideaki Mizuno, Motonobu Yoshida, Ryuji Yoshino, Biswa Nath Mitra, Min Pi, Tomihiro Sato, Keiko Takemoto, Hiroo Yasukawa, Jeffrey Williams, Mineko Maeda, Ikuo Takeuchi, Hiroshi Ochiai, Yoshimasa Tanaka

DNA Research, 5(6) 335-340, 1998 Peer-reviewed

	Pre-clinical investigation of predictive biomarkers for drug candidates using a molecularly profiled large cancer cell line panel. Satoshi Aida, Hideaki Mizuno, Hiroshi Sakamoto, Yoshito Nakanishi, Hironori Mutoh, James Cai, Helmut Burtscher, Masahiro Aoki, Yuko Aoki, Nobuya Ishii. Mol Cancer Ther 2013, 12:A41.
	Phylogenetic Analysis of Essential Genes by Using ORI-GENE. Kawano H, Mizuno H, Sarai A. Genome Informatics 2006. pdf
	ORI-GENE: A tool for gene analysis based on evolutionary tree. Mizuno H, Tanaka Y, Sarai A. Forty-sixth Annual Meeting of the Biophysical Society of Japan.
	ORI-GENE: A tool for gene analysis based on evolutionary tree - Application to cDNA project of Dictyostelium discoideum. Mizuno H, Sarai A, Tanaka Y. Dictyostelium international 1999. pdf
	ORI-GENE: A Tool for Gene Classification Based on Evolutional Tree. Mizuno H, Tanaka Y, Ugawa Y, Sarai A. Genome Informatics 1998. pdf